ElShamah Ministries: Defending the Christian Worldview and Creationism
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ElShamah Ministries: Defending the Christian Worldview and Creationism

Otangelo Grasso: This is my personal virtual library, where i collect information, which leads in my view to the Christian faith, creationism, and Intelligent Design as the best explanation of the origin of the physical Universe, life, and biodiversity

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Proteins that work together to permit rapid Communication by Brain Cells: By evolution, or design?

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Proteins that work together to permit rapid Communication by Brain Cells: By evolution, or design?

Three proteins help brain cells synchronize the release of chemical signals. A similar interaction may play a role in how cells secrete insulin and airway mucus, too.

A complex of three proteins (shown at right in the picture) helps brain cells quickly release neurotransmitters (light green) to communicate with neighboring cells. 
An intricate new three-dimensional protein structure is providing a detailed look into how brain cells communicate rapidly.
By visualizing how three neural proteins interact with one another, researchers have revealed how they help groups of brain cells release chemical messages at the same time.
The work describes a surprising new cooperation among the three proteins, and could offer insight into other processes where cells secrete molecules, including insulin and airway mucus. Howard Hughes Medical Institute (HHMI) Investigator Axel Brunger and colleagues report the results August 24 in the journal Nature.

When a group of neurons receives an electrical signal, the cells release chemicals called neurotransmitters nearly instantaneously – within less than one thousandth of a second. Neurons hold neurotransmitters in bubble-like structures called synaptic vesicles. These structures rest inside the end of long, thin projections that point toward neighboring cells. To free neurotransmitters from their bubbles, neurons must fuse vesicle membranes with the outer membrane of the projections. This opens the bubbles and dumps their contents into the space between cells. The chemical signals then float to neighboring cells to relay a message.
Scientists knew that three proteins are involved in spitting out neurons’ chemical signals. 

A group of proteins called SNAREs provides energy for membrane fusion. 
Another protein, called synaptotagmin, releases neurotransmitters when calcium ions appear following an electrical signal. 
A third protein, complexin, prevents cells from spontaneously releasing neurotransmitters. Synaptotagmin and complexin each partner with SNARE proteins,  now scientists can explain how these three components work together.

The crystal structure revealed two ways that the proteins interact. The first interaction – between synaptotagmin and the SNARE proteins – is identical to one Brunger and colleagues described in a 2015 paper in Nature. A second, unexpected, interaction revealed a relationship between all three components in the larger complex.

My comment: This seems another example of integrated complexity, where three componets share the task in a joint venture, to achieve a specific goal. This seems another fine example of irreducible complexity, where either everything is in place to work together, or nothing goes. The designers creative power is awe-inspiring, and unfathomable. 


More about SNARE proteins:

Proteins that work together to permit rapid Communication by Brain Cells: By evolution, or design? COVERS-Brunger_crop_700x400


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