The seven day Circadian Rhythms: "Nature's Intricate Clockwork"

The seven day Circadian Rhythms: "Nature's Intricate Clockwork"

https://reasonandscience.catsboard.com/t1487-the-seven-day-circadian-rhythms-nature-s-intricate-clockwork



It is already known that the human body maintains its own biological clock. He has a "circadian rhythm" internal 24 hours that drives the increase and the reduction of many molecules. Chronobiology has documented how human beings are highly rhythmic. Most of the many tick tacks are difficult to detect; they operate just below the human consciousness. Innate and hidden in the cell structure, the mysteries of biological time have been revealed by modern computers and scientific advance. I knew about the 24 hours  circadian rhytm for some time, but surprisingly there is also a 7-day cycle (Circaseptan Rhythm) . It was detected  and related to the record of geomagnetic disturbances (Kp-Index) over a time period of 59-years, (Halberg 1991)  Jeremy Campbell says in his book: "The circaceptan pace is one of the big surprises that emerged in modern Chronobiology. Some years ago, few scientists would have expected that biological cycles of seven days would become  so widespread and established.

The existence of such precise circaceptan endogenous rhythms (including the need to seven days excretion of 17-ketosteroids [urinary metabolites] in healthy men) suggests that all circaceptanos rhythms are endogenous actually - described as a "built-in" (genetically determined) on the exact period of seven days. 1


What’s the Healthiest Day?: Circaseptan (Weekly) Rhythms in Healthy Considerations 2
Biological clocks govern numerous aspects of human health, including weekly clocks–called circaseptan rhythms–that typically include early-week spikes for many illnesses.

Conclusions
Just as many illnesses have a weekly clock, so do healthy considerations. Discovery of these rhythms opens the door for a new agenda in preventive medicine, including implications for hypothesis development, research strategies to further explore these rhythms, and interventions to exploit daily cycles in healthy considerations.

Moreover, a seven-day cycle was found in the blood pressure fluctuations in the acid content in the blood, in erythrocytes, in a heartbeat, the oral temperature, the temperature of the female breast, chemical and urine volume, rate of two important neurotransmitters - norepinephrine and epinephrine - and the increase and decrease of various body chemicals, such as coping stress hormone, cortisol. 3

http://www.godward.org/archives/Special%20Articles/7-Day%20Cycle.htm

"By the seventh day God had finished the work he had been doing; so on the seventh day he rested from all his work. And God blessed the seventh day and made it holy, because on it he rested from all the work of creating that he had done" (Gen 2:2-3).

His last act in the creation week was to rest and make holy the seventh day as a memorial to his creation. He closed the cycle of creation at seven days and set the clock of time moving forward to this day. In all life resides that circaseptan beat echoing, like a rifle shot in a vast rock canyon, backward in time to the first seven days of dynamic creation.

Each living thing made testifies of brilliant design, of divine craftsmanship, of marvelous function, of intricate interactions with the environment and other life forms, of mystery, of beauty. From roses to redwoods, from salmon to sharks, from elephants to eagles, all life cries to be inspected, admired and praised for its peculiar display of divine handiwork. Even man marvels in awe when he beholds himself:

"For you created my inmost being; you knit me together in my mother's womb. I praise you because I am fearfully and wonderfully made; your works are wonderful, I know that full well" (Ps 139:13-14).

The fingerprints of a divine creator cover his creation. To behold life on earth in its billions of varieties and go forth claiming it to be the result of blind, random, evolutionary accidents, takes a "faith" and a "belief" that defies understanding or logic.

They are of ancient origin, appearing in primitive single-celled organisms, and are thought to be present even in bacteria, the simplest form of life now existing "(p.75).

Wiki confirms:

The circadian rythm is as old as life, existing in Cianobacteria. According to Wiki : The variations of the timing and duration of biological activity in living organisms occur for many essential biological processes. These occur (a) in animals (eating, sleeping, mating, hibernating, migration, cellular regeneration, etc.), (b) in plants (leaf movements, photosynthetic reactions, etc.), and in microbial organisms such as fungi and protozoa. They have even been found in bacteria, especially among the cyanobacteria (aka blue-green algae, see bacterial circadian rhythms). The most important rhythm in chronobiology is the circadian rhythm, a roughly 24-hour cycle shown by physiological processes in all these organisms. How could such sophisticated mechanisms be result of natural , unguided mechanisms ? hard to believe...

The circadian "clock" in humans

http://en.wikipedia.org/wiki/Suprachiasmatic_nucleus

The circadian "clock" in humans is located mainly in the suprachiasmatic nucleus (SCN), which is a group of cells located in the hypothalamus (a portion of the brain).The suprachiasmatic nucleus or nuclei (SCN) is a tiny region located in the hypothalamus, situated directly above the optic chiasm. It is responsible for controlling circadian rhythms. The neuronal and hormonal activities it generates regulate many different body functions in a 24-hour cycle, using around 20,000 neurons.[1] The SCN interacts with many other regions of the brain. It contains several cell types and several different peptides (including vasopressin and vasoactive intestinal peptide) and neurotransmitters.

I knew about the 24h  circadian rhytm for some time, but surprisingly there is also a 7-day cycle (Circaseptan Rhythm)
What’s the Healthiest Day?: Circaseptan (Weekly) Rhythms in Healthy Considerations

http://en.wikipedia.org/wiki/Circadian_rhythm

A circadian rhythm  is any biological process that displays an endogenous, entrainable oscillation of about 24 hours. These rhythms are driven by a circadian clock, and rhythms have been widely observed in plants, animals, fungi and cyanobacteria. The term circadian comes from the Latin circa, meaning "around" (or "approximately"), and diem or dies, meaning "day". The formal study of biological temporal rhythms, such as daily, tidal, weekly, seasonal, and annual rhythms, is called chronobiology. Although circadian rhythms are endogenous ("built-in", self-sustained), they are adjusted (entrained) to the local environment by external cues called zeitgebers, commonly the most important of which is daylight.

http://www.evolutionnews.org/2012/09/circadian_rhyth063881.html

"Over the past decade, remarkable progress has been made in elucidating the molecular genetics of these single-cell oscillators," he writes. "More recently, structural biology has begun to contribute a detailed picture of our clock components." The ghost of William Paley studying components of a watch found on a heath rises at the sound of statements like this. (Emphasis added in all quotations.)

Crane was commenting on work by Huang et al., in the same issue of Science. (see our June 5 article). They identified two proteins that are part of the "autoregulatory transcriptional feedback mechanism that takes approximately 24 hours to complete." The proteins form a complex that "controls the expression of numerous genes, including those that code for the oscillator proteins of the clock itself." These proteins, CLOCK and BMAL1, are "made up of two domains that are found throughout biology, serving a range of functions." Moreover, they contain numerous interfaces to other proteins.

http://www.sciencemag.org/content/337/6091/165.summary

Much of human physiology and behavior is influenced by circadian rhythms. Whether you burned the midnight oil, rose at the crack of dawn, or enjoyed your rest last night, tiny clocks in your cells have been trying to keep you on schedule. Over the past decade, remarkable progress has been made in elucidating the molecular genetics of these single-cell oscillators. More recently, structural biology has begun to contribute a detailed picture of our clock components.

The circadian clock is like an orchestra with many conductors

http://phys.org/news/2014-03-circadian-clock-orchestra-conductors.html

http://www.suspicious0bserverscollective.org/the-blog/rhythms-of-life-circadian-circaseptan-schumann-resonances-human-health

In addition to the Circadian Rhythm, which is a bi-product of the 24-hour rotational cycle (day/night) of the Earth, there is the Circaseptan Rhythm, a 7-day cycle that correlates to the Geomagnetic Activity of Earth. As detailed in Dr. Cherry's model, changes in the Schumann Resonance via S-GMA induces changes in the cellular calcium ion signals, brain wave patterns and reactions times which produces altered melatonin/serotonin production. When this neurohormone chemistry is altered by the circadian cycle, a wide range of organs and bodily processes are influenced affecting human health.



1. Levi F, Halberg F. Circaseptan (about-7-day) bioperiodicity - spontaneous and reactive -and the search for pacemakers. Ric Clin Lab. 1982 Apr-Jun;12(2):323-70. http://www.ncbi.nlm.nih.gov/pubmed/7111982
2. http://www.sciencedirect.com/science/article/pii/S0749379714000993
3. Haus E .Chronobiology in the endocrine system. Adv Drug Deliv Rev. 2007; 59(9-10):985-1014. http://www.ncbi.nlm.nih.gov/pubmed/17804113

read more :

http://reasonandscience.heavenforum.org/t1487-the-seven-day-circadian-rhythms-nature-s-intricate-clockwork#2164

The circadian clock plays a crucial role in the regulation of almost every physiological process. 2 Now it is apparent that almost all facets of physiology display rhythmic oscillations from the simplest archaebacteria to humans; these rhythms are controlled by an internal circadian clock.  The circadian clock can be divided into two major components:

- the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and
- the peripheral clocks that are present in nearly every tissue and organ system.

Light signals and other external factors such as feeding cues entrain the central circadian clock, which in turn synchronize the peripheral clocks. The peripheral clocks play an integral and unique role in each of their respective tissues, driving the circadian expression of specific genes involved in a variety of physiological functions. 3 Light enters through the retina of the eye, causing electrical signals to pass through the retinal hypothalamic tract, which are converted to chemical signals in the SCN. Light signals and other physiological factors, such as feeding cues, entrain the central circadian clock. Blood pressure drops at night and rises during the day. Individuals who do not experience this nighttime “dip” in blood pressure are known as “nondippers” and have an increased risk for adverse cardiovascular events. Blood flow in humans exhibits a circadian rhythm.

The rotation of the earth on its axis creates the environment of a 24 h solar day, which organisms on earth have used to their advantage by integrating this timing information into their genetic make-up in the form of a circadian clock. This intrinsic molecular clock is pivotal for maintenance of synchronized homeostasis between the individual organism and the external environment to allow coordinated rhythmic physiological and behavioral function. 1


The interdependent relationship of the circadian clock of individual cell, and the central clock in the brain: By evolution, or design? 

The circadian clock plays a crucial role in the regulation of almost every physiological process.

Biological life is a complicated and extraordinary process that co-exists in a coordinated, rhythmic symphony with the external environment. Perhaps the most consistent environmental influence on life is the rotation of the Earth about its axis, partitioning each 24 h day into a recurrent period of light and darkness. The environmental pressure of the solar day is so influential that organisms have incorporated this timing feature into their genomes, in the form of a molecular clock that allows synchronization of physiological function with the diurnal rhythms of the environmental light cycle.

When this biological clock is constitutively disrupted or the expression and rhythm of genes controlling the circadian clock are disturbed by certain factors, like shift-work, organisms cannot rectify variations in external conditions with internal clock status, leading to pathologic states, including metabolic syndrome, immune-related and neoplastic disease and others. It is increasingly recognized that maintaining the health of the intrinsic molecular clock, which controls the periodic secretion of hormones and enzyme activities, metabolism and food intake, is critical to human health.

At the molecular level, the mammalian circadian clock exists as interlocked, autoregulatory transcriptional/translational feedback loops (TTFL)

An individual cell’s clock mechanism is based on timed feedback loops of interacting genes. Clock genes, components of the body’s internal timekeeping system, are both stimulated and inhibited by RNA and protein molecules. A gene is triggered, producing a protein or RNA, which then triggers a second gene in the circuit. The second gene product stimulates a third gene, and so on. These events form a cycle that lasts twenty-four hours. 4 While all cells have the same basic genetic clock machinery, various RNA's and proteins specific to each type of cell and organ are signals that produce various clock functions. A huge amount of all RNA's—at least 10 percent—are related to tags and signals for clocks. Multiple layers of genetic regulation influence these cycles. For example, very recently a new form of regulation was discovered that alters three-dimensional structures of the DNA molecule in the nucleus. When the structure changes, it alters how physically close particular genes are to each other. Bringing certain genes near each other can synchronize clock functions. Multiple influences affect clock rhythms. Signals from metabolic cycles alter specific RNA's and proteins to influence clock genes. Various chemicals in particular organs affect clocks in different ways. Global factors, such as temperature and other environmental conditions, alter gene function. Many of these complex clock signals for individual cells are not yet understood.

When tissue cannot sync with the central brain mechanisms, illness can occur. One issue that needs to be addressed is our twenty-fourhours-a-day, seven-days-a-week online culture, which pays no attention to the rhythms corresponding to daylight that are established in our organism. 

Question: How can evolution explain the interrelationship and synchronization of the individual circadian rhythm clocks of the peripheral clocks that are present in nearly every tissue and organ system. with the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain ? And even more, how can we explain the clock cycles in the liver and pancreas, which operate on opposite schedules ?

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139808/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073891/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425819/
4. The secret language of Cells, Jon Lieff, page 31

The interdependent relationship of the circadian clock of individual cells, and the central clock in the brain: By evolution, or design? 

https://reasonandscience.catsboard.com/t1487-the-seven-day-circadian-rhythms-nature-s-intricate-clockwork#8119

The circadian clock plays a crucial role in the regulation of almost every physiological process.

Biological life is a complicated and extraordinary process that co-exists in a coordinated, rhythmic symphony with the external environment. Perhaps the most consistent environmental influence on life is the rotation of the Earth about its axis, partitioning each 24 h day into a recurrent period of light and darkness. The environmental pressure of the solar day is so influential that organisms have incorporated this timing feature into their genomes, in the form of a molecular clock that allows synchronization of physiological function with the diurnal rhythms of the environmental light cycle.

When this biological clock is constitutively disrupted or the expression and rhythm of genes controlling the circadian clock are disturbed by certain factors, like shift-work, organisms cannot rectify variations in external conditions with internal clock status, leading to pathologic states, including metabolic syndrome, immune-related and neoplastic disease and others. It is increasingly recognized that maintaining the health of the intrinsic molecular clock, which controls the periodic secretion of hormones and enzyme activities, metabolism and food intake, is critical to human health.

At the molecular level, the mammalian circadian clock exists as interlocked, autoregulatory transcriptional/translational feedback loops (TTFL)

An individual cell’s clock mechanism is based on timed feedback loops of interacting genes. Clock genes, components of the body’s internal timekeeping system, are both stimulated and inhibited by RNA and protein molecules. A gene is triggered, producing a protein or RNA, which then triggers a second gene in the circuit. The second gene product stimulates a third gene, and so on. These events form a cycle that lasts twenty-four hours. 4 While all cells have the same basic genetic clock machinery, various RNA's and proteins specific to each type of cell and organ are signals that produce various clock functions. A huge amount of all RNA's—at least 10 percent—are related to tags and signals for clocks. Multiple layers of genetic regulation influence these cycles. For example, very recently a new form of regulation was discovered that alters three-dimensional structures of the DNA molecule in the nucleus. When the structure changes, it alters how physically close particular genes are to each other. Bringing certain genes near each other can synchronize clock functions. Multiple influences affect clock rhythms. Signals from metabolic cycles alter specific RNA's and proteins to influence clock genes. Various chemicals in particular organs affect clocks in different ways. Global factors, such as temperature and other environmental conditions, alter gene function. Many of these complex clock signals for individual cells are not yet understood.

When tissue cannot sync with the central brain mechanisms, illness can occur. One issue that needs to be addressed is our twenty-fourhours-a-day, seven-days-a-week online culture, which pays no attention to the rhythms corresponding to daylight that are established in our organism. 

Question: How can evolution explain the interrelationship and synchronization of the individual circadian rhythm clocks of the peripheral clocks that are present in nearly every tissue and organ system. with the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain ? And even more, how can we explain the clock cycles in the liver and pancreas, which operate on opposite schedules ?

1. The God of the Bible is the author of the 7-day cycle as a temporal reference framework. He also established the Sabbath in Genesis.  
2. Biological organisms are programmed to rest on the seventh day through the 7-day circadian rhythm.
3. Isaiah 66.23 predicted the universal application of the 7-day cycle which is fulfilled in the fact that not only those that worship Jahweh, God of the Bible, but everyone, all cultures believing in other deities with their costumes, rites, and calendars, have adopted the 7-day cycle, and replaced the other cycles of the other Gods. During the french revolution, an attempt was made to replace it with the French Revolutionary calendar, where the day had only 10 hours, and the tenth day, décadi, replaced Sunday as the day of rest and festivity. It lasted only for 12 years, from 1793 to 1805.
3. Therefore, the God of the Bible demonstrates that he not only created life, and built-in the biological clock to adopt the 7-day cycle. He is also Lord over the nations, and above all human-invented Gods, and their calendars, rules, and costumes.  

The seven-day Circadian Rhythms: "Nature's Intricate Clockwork"
https://reasonandscience.catsboard.com/t1487-the-seven-day-circadian-rhythms-nature-s-intricate-clockwork

https://www.youtube.com/watch?v=pC0TngX6uc4

Isaiah 66.23 (KJV) And it shall come to pass, that from one new moon to another, and from one sabbath to another, shall all flesh come to worship before me, saith the LORD.


P1 - The God of the Hebrews is the author of the 7 day cycle
P2 - God predicted the universal application of the 7-day cycle would be used by everyone and replace the other cycles of the other Gods, and that was fulfilled.  

Power of the nations shows that he is sovereign over the nations. All the nations were relinquished their system in favor of the 7-day cycle
The 7 day cycle predates Rome, and Constantine

babylonian tablets: enuma elish cycle, 8 or 9 day cycle , 5th tablet

David C S Wong: CRYPTOCHROMES promote daily protein homeostasis 29 November 2021
The daily organisation of most mammalian cellular functions is attributed to circadian regulation of clock-controlled protein expression, driven by daily cycles of CRYPTOCHROME-dependent transcriptional feedback repression. To test this, we used quantitative mass spectrometry to compare wild-type and CRY-deficient fibroblasts under constant conditions. In CRY-deficient cells, we found that temporal variation in protein, phosphopeptide, and K+ abundance was at least as great as wild-type controls. Most strikingly, the extent of temporal variation within either genotype was much smaller than overall differences in proteome composition between WT and CRY-deficient cells. This proteome imbalance in CRY-deficient cells and tissues was associated with increased susceptibility to proteotoxic stress, which impairs circadian robustness, and may contribute to the wide-ranging phenotypes of CRY-deficient mice. Rather than generating large-scale daily variation in proteome composition, we suggest it is plausible that the various transcriptional and post-translational functions of CRY proteins ultimately act to maintain protein and osmotic homeostasis against daily perturbation.
https://www.embopress.org/doi/full/10.15252/embj.2021108883