The origin of the first cell, cannot be explained by natural selection 1
‘In reading some other literature on the origin of life, I am afraid that not all authors have used the term [natural selection] carefully. Natural selection is differential reproduction, organism perpetuation. In order to have natural selection, you have to have self-reproduction or self-replication and at least two distinct self-replicating units or entities. … I would like to plead with you, simply, please realize you cannot use the words “natural selection” loosely. Prebiological natural selection is a contradiction of terms. 2
“DNA is not a special life-giving molecule, but a genetic databank that transmits its information using a mathematical code. Most of the workings of the cell are best described, not in terms of material stuff — hardware — but as information, or software. Trying to make life by mixing chemicals in a test tube is like soldering switches and wires in an attempt to produce Windows 98. It won’t work because it addresses the problem at the wrong conceptual level.”
2) Dobzhansky, T.G., Discussion of Synthesis of Nucleosides and Polynucleotides with Metaphoric Esters, by George Schramm, in Fox, S.W., ed., The Origins of Prebiological Systems and of Their Molecular Matrices, Proceedings of a Conference Conducted at Wakulla Springs, Florida, pp. 309–310, 27–30 October 1963, Academic Press, NY, 1965.