One of the often heard rebuttals of atheists which use evolution as crutches to back up their views that God is not required is:
" You don't know how evolution works".
This demonstrates that:
They do think they know how evolution works. and that they, in reality, have NO CLUE what they are talking about.
In the same sense, as on top of making complex factories, first is the elaboration of a master plan, a general layout of an industrial complex of various interlinked factory buildings, and below are the blueprints to make the individual factories, compartments, assembly lines, machines, robots, machine elements, basic building blocks, material specification, etc.
in biology, there is as well a master plan, which outlines the entire structure and body architecture of an organism. That master plan is stored in the genome, in a section, called homeobox.
Homeobox genes are a large family of similar genes that direct the formation of many body structures during early embryonic development. A homeobox is a DNA sequence found within genes that are involved in the regulation of patterns of anatomical development morphogenesis in animals, fungi, and plants. In humans, the homeobox gene family contains an estimated 235 functional genes and 65 pseudogenes, which are structurally similar genes that do not provide instructions for making proteins. Homeobox genes are present on every human chromosome, and they often appear in clusters. Many classes and subfamilies of homeobox genes have been described, although these groupings are used inconsistently.
Homeoboxes have been found in fungi, plants and animals. In each "kingdom" homeobox genes occupy a key position in the genetic control of either cell differentiation, morphogenesis and or body plan specification.
The degree of sequence conservation of the homeodomain is extremely high indicating strong functional constraints leading to a high pressure to retain the homeobox sequences constant.
Single mutations in HOXA1 sequence, is crucial in the determination of severe cardiovascular malformations. Mice knock out for Hoxa1, show defects as interrupted aortic arch, aberrant subclavian artery and Tetralogy of Fallot. Hoxa1 play a key role in the arrangement of the great arteries and heart outflow tract.
Mice knockout for Hoxa3 gene, show cardiac abnormalities and links between circulatory and respiratory systems. The HOXC5, HOXA5 and HOXB5 expression, induce a development of new pharyngeal arches containing a new aortic arch artery with regular flow. HOXC9 is overexpressed, in human smooth muscle cells and the cardiovascular system during embryogenesis.
What does that demonstrate? In a vast gene sequence space, functional Gene regulatory sequences, Master genes that direct body development, are under severe constraint, and only very specific homeobox sequences are functional, and even A SINGLE MUTATION has catastrophic consequences.
SORRY, Charly, but once again, your ideas are being refuted and falsified. Sad that you are not here to clean up the mess you left, and so many still believe in your unproven claims, nothing else than guesswork, which is driving so many away from the MASTER, that invented all this stuff.
So. What does science say to this ?? Lets see.
Evolution of Homeobox Gene Clusters in Animals: The Giga-Cluster and Primary vs. Secondary Clustering
There is uncertainty in our understanding of homeobox gene cluster evolution at present. This relates to our still rudimentary understanding of the dynamics of genome rearrangements and evolution over the evolutionary timescales being considered when we compare lineages from across the animal kingdom.
OH NO !!! I can't believe it !! They have no clue? Right. Pro scientists working on the field which try to find out how the instructions of gene expression and repression emerged, admit, they have no idea !!
Well, they are at least honest to admit the situation.
But the ultracrepidarian " i know it better " experts we deal with on FB feel themselves in the position to tell us the Levites, and educate us on evolutionary developmental biology. We, creationists, are the don't know ists and ignorantes, who do have no clue how evolution works... HÁ !!