Defending the Christian Worlview, Creationism, and Intelligent Design
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Defending the Christian Worlview, Creationism, and Intelligent Design

This is my personal virtual library, where i collect information, which leads in my view to the Christian faith, creationism, and Intelligent Design as the best explanation of the origin of the physical Universe, life, and biodiversity

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Defending the Christian Worlview, Creationism, and Intelligent Design » Origin of life » Compounds that have no explanation at all how they could have been synthesized prebiotically

Compounds that have no explanation at all how they could have been synthesized prebiotically

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Compounds that have no explanation at all how they could have been synthesized prebiotically

Organic compounds would need to be concentrated and complexified by environmental mechanisms. 1  The origin of life remains unexplained despite decades (or perhaps centuries, depending on where one historically marks the starting point) of research.

In some syntheses, the concentrations must be so high (e.g., 10 M formaldehyde) that the syntheses could not be expected to have occurred on the primitive Earth. Reactions under these and other extreme conditions cannot be
considered plausibly prebiotic. Following  important biological compounds  do not have adequate prebiotic syntheses:

1. arginine
2. lysine
3. histidine

4. porphyrins

5. riboflavin
Coenzymes are essential across all domains of life. B vitamins (B1-thiamin, B2- riboflavin, B3-niacin, B5-pantothenate, B6-pyridoxine, B7-biotin, and B12-cobalamin) represent the largest class of coenzymes, which participate in a diverse set of reactions including C1-rearrangements, DNA repair, electron transfer, and fatty acid synthesis. 2

6. pyridoxal folic acid
Vitamin B6 is one of the most central molecules in cells of living organisms. It is a critical co-factor for a diverse range of biochemical reactions that regulate basic cellular metabolism, which impact overall physiology. 3

7. thiamine
Biotin, thiamine, and CoA are essential cofactors 4

8. lipoic acid

9. Straight-chain fatty acids
High concentrations of osmotically active salts inhibit the ability of membranous vesicles to form because the internal volume cannot increase unless the membrane is sufficiently permeable for the salt to equilibrate between the internal and external phases. The other problem occurs if the external medium becomes diluted. As a result, the compartment swells as water diffuses inward across the boundary membrane and may even burst, releasing the internal contents.

10. biotin


Amino Acids:
Gaseous NH3 is rapidly decomposed by ultraviolet light, and during Archean times, the absence of a significant ozone layer would have limited NH3's atmospheric concentration. 1 Without added H2, amino acid yields are quite low, especially when CO2 is the sole carbon source

Lipids and Membrane-Forming Compounds
Most prebiotic simulations don't generate large amounts of fatty acids, with the exception of some hydrothermal vent simulations, which may use concentrations of reactants which are unreasonably high for these environments. The Murchison CC contains small amounts of straight-chain fatty acids, though some of these may be contamination. 5



Some important biological compounds that do not yet have adequate prebiotic syntheses are the following: 

folic acid 
lipoic acid 
straight-chain fatty acids 

It is probable that plausible prebiotic syntheses will become available before too long for some of these compounds. In other cases, the compounds may not have been synthesized prebiotically, their occurrence in living systems being a result of intracellular biochemical evolution that occurred after the origin of life.

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