Mutations are rarely beneficial
Mutations are the only known means by which new genetic material becomes available for evolution.a Rarely, if ever, is a mutation beneficial to an organism in its natural environment. Almost all observable mutations are harmful; some are meaningless; many are lethal. No known mutation has ever produced a form of life having greater complexity and viability than its ancestors.
a . “Ultimately, all variation is, of course, due to mutation.” Ernst Mayr, “Evolutionary Challenges to the Mathematical Interpretation of Evolution,” Mathematical Challenges to the Neo-Darwinian Interpretation of Evolution, editors Paul S. Moorhead and Martin M. Kaplan, proceedings of a symposium held at the Wistar Institute of Anatomy and Biology, 25–26 April, 1966 (Philadelphia: The Wistar Institute Press, 1967), p. 50.
u “Although mutation is the ultimate source of all genetic variation, it is a relatively rare event, ...” Ayala, p. 63.
b . “The process of mutation is the only known source of the raw materials of genetic variability, and hence of evolution. ... the mutants which arise are, with rare exceptions, deleterious to their carriers, at least in the environments which the species normally encounters.” Theodosius Dobzhansky, “On Methods of Evolutionary Biology and Anthropology,” American Scientist, December 1957, p. 385.
u “In molecular biology, various kinds of mutations introduce the equivalent of noise pollution of the original instructive message. Communication theory goes to extraordinary lengths to prevent noise pollution of signals of all kinds. Given this longstanding struggle against noise contamination of meaningful algorithmic messages, it seems curious that the central paradigm of biology today attributes genomic messages themselves solely to noise.” David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, p. 10. (Also available at www.tbiomed.com/content/2/1/29.)
u “Accordingly, mutations are more than just sudden changes in heredity; they also affect viability, and, to the best of our knowledge, invariably affect it adversely.” C. P. Martin, “A Non-Geneticist Looks at Evolution,” American Scientist, January 1953, p. 102.
“Mutation does produce hereditary changes, but the mass of evidence shows that all, or almost all, known mutations are unmistakably pathological and the few remaining ones are highly suspect.” Ibid., p. 103.
“[Although mutations have produced some desirable breeds of animals and plants,] all mutations seem to be in the nature of injuries that, to some extent, impair the fertility and viability of the affected organisms. I doubt if among the many thousands of known mutant types one can be found which is superior to the wild type in its normal environment, only very few can be named which are superior to the wild type in a strange environment.” Ibid., p. 100.
u “If we say that it is only by chance that they [mutations] are useful, we are still speaking too leniently. In general, they are useless, detrimental, or lethal.” W. R. Thompson, “Introduction to The Origin of Species,” Everyman Library No. 811 (New York: E. P. Dutton & Sons, 1956; reprint, Sussex, England: J. M. Dent and Sons, Ltd., 1967), p. 10.
u Visible mutations are easily detectable genetic changes, such as albinism, dwarfism, and hemophilia. Winchester quantifies the relative frequency of several types of mutations.
Lethal mutations outnumber visibles by about 20 to 1. Mutations that have small harmful effects, the detrimental mutations, are even more frequent than the lethal ones. Winchester, p. 356.
u John W. Klotz, Genes, Genesis, and Evolution, 2nd edition, revised (St. Louis: Concordia Publishing House, 1972), pp. 262–265.
u “... I took a little trouble to find whether a single amino acid change in a hemoglobin mutation is known that doesn’t affect seriously the function of that hemoglobin. One is hard put to find such an instance.” George Wald, as quoted by Murray Eden, “Inadequacies of Neo-Darwinian Evolution as a Scientific Theory,” Mathematical Challenges to the Neo-Darwinian Interpretation of Evolution, editors Paul S. Moorhead and Martin M. Kaplan, pp. 18–19.
However, evolutionists have taught for years that hemoglobin alpha changed through mutations into hemoglobin beta. This would require, at a minimum, 120 point mutations, so the improbability Wald refers to above must be raised to the 120th power to produce just this one protein!
u “Even if we didn’t have a great deal of data on this point, we could still be quite sure on theoretical grounds that mutants would usually be detrimental. For a mutation is a random change of a highly organized, reasonably smoothly functioning living body. A random change in the highly integrated system of chemical processes which constitute life is almost certain to impair it—just as a random interchange of connections in a television set is not likely to improve the picture.” James F. Crow (Professor of Genetics, University of Wisconsin), “Genetic Effects of Radiation,” Bulletin of the Atomic Scientists, Vol. 14, January 1958, pp. 19–20.
u “The one systematic effect of mutation seems to be a tendency towards degeneration ...” [emphasis in original] Sewall Wright, “The Statistical Consequences of Mendelian Heredity in Relation to Speciation,” The New Systematics, editor Julian Huxley (London: Oxford University Press, 1949), p. 174.
Wright then concludes that other factors must also have been involved, because he believes evolution happened.
u In discussing the many mutations needed to produce a new organ, Koestler says:
Each mutation occurring alone would be wiped out before it could be combined with the others. They are all interdependent. The doctrine that their coming together was due to a series of blind coincidences is an affront not only to common sense but to the basic principles of scientific explanation. Arthur Koestler, The Ghost in the Machine (New York: Macmillan Publishing Co., 1968), p. 129.
c . “There is no single instance where it can be maintained that any of the mutants studied has a higher vitality than the mother species.” N. Heribert Nilsson, Synthetische Artbildung (Lund, Sweden: Verlag CWK Gleerup, 1953), p. 1157.
“It is, therefore, absolutely impossible to build a current evolution on mutations or on recombinations.” [emphasis in original] Ibid., p. 1186.
u “No matter how numerous they may be, mutations do not produce any kind of evolution.” Pierre-Paul Grassé, Evolution of Living Organisms (New York: Academic Press, 1977), p. 88.
u “I have seen no evidence whatsoever that these [evolutionary] changes can occur through the accumulation of gradual mutations.” Lynn Margulis, as quoted by Charles Mann, “Lynn Margulis: Science’s Unruly Earth Mother,” Science, Vol. 252, 19 April 1991, p. 379.
u “It is true that nobody thus far has produced a new species or genus, etc., by macromutation. It is equally true that nobody has produced even a species by the selection of micromutations.” Richard B. Goldschmidt, “Evolution, As Viewed by One Geneticist,” American Scientist, Vol. 40, January 1952, p. 94.
u “If life really depends on each gene being as unique as it appears to be, then it is too unique to come into being by chance mutations.” Frank B. Salisbury, “Natural Selection and the Complexity of the Gene,” Nature, Vol. 224, 25 October 1969, p. 342.
u “Do we, therefore, ever see mutations going about the business of producing new structures for selection to work on? No nascent organ has ever been observed emerging, though their origin in pre-functional form is basic to evolutionary theory. Some should be visible today, occurring in organisms at various stages up to integration of a functional new system, but we don’t see them: there is no sign at all of this kind of radical novelty. Neither observation nor controlled experiment has shown natural selection manipulating mutations so as to produce a new gene, hormone, enzyme system or organ.” Michael Pitman, Adam and Evolution (London: Rider & Co., 1984), pp. 67–68.
u For a multifaceted genetic analysis that devastates the idea that mutations and natural selection can produce, or even maintain, viable organisms, see John C. Sanford, Genetic Entropy & the Mystery of the Genome (Waterloo, New York: FMS Publications, 2005).
Mutations are the only known means by which new genetic material becomes available for evolution.a Rarely, if ever, is a mutation beneficial to an organism in its natural environment. Almost all observable mutations are harmful; some are meaningless; many are lethal. No known mutation has ever produced a form of life having greater complexity and viability than its ancestors.
a . “Ultimately, all variation is, of course, due to mutation.” Ernst Mayr, “Evolutionary Challenges to the Mathematical Interpretation of Evolution,” Mathematical Challenges to the Neo-Darwinian Interpretation of Evolution, editors Paul S. Moorhead and Martin M. Kaplan, proceedings of a symposium held at the Wistar Institute of Anatomy and Biology, 25–26 April, 1966 (Philadelphia: The Wistar Institute Press, 1967), p. 50.
u “Although mutation is the ultimate source of all genetic variation, it is a relatively rare event, ...” Ayala, p. 63.
b . “The process of mutation is the only known source of the raw materials of genetic variability, and hence of evolution. ... the mutants which arise are, with rare exceptions, deleterious to their carriers, at least in the environments which the species normally encounters.” Theodosius Dobzhansky, “On Methods of Evolutionary Biology and Anthropology,” American Scientist, December 1957, p. 385.
u “In molecular biology, various kinds of mutations introduce the equivalent of noise pollution of the original instructive message. Communication theory goes to extraordinary lengths to prevent noise pollution of signals of all kinds. Given this longstanding struggle against noise contamination of meaningful algorithmic messages, it seems curious that the central paradigm of biology today attributes genomic messages themselves solely to noise.” David L. Abel and Jack T. Trevors, “Three Subsets of Sequence Complexity and Their Relevance to Biopolymeric Information,” Theoretical Biology & Medical Modelling, Vol. 2, 11 August 2005, p. 10. (Also available at www.tbiomed.com/content/2/1/29.)
u “Accordingly, mutations are more than just sudden changes in heredity; they also affect viability, and, to the best of our knowledge, invariably affect it adversely.” C. P. Martin, “A Non-Geneticist Looks at Evolution,” American Scientist, January 1953, p. 102.
“Mutation does produce hereditary changes, but the mass of evidence shows that all, or almost all, known mutations are unmistakably pathological and the few remaining ones are highly suspect.” Ibid., p. 103.
“[Although mutations have produced some desirable breeds of animals and plants,] all mutations seem to be in the nature of injuries that, to some extent, impair the fertility and viability of the affected organisms. I doubt if among the many thousands of known mutant types one can be found which is superior to the wild type in its normal environment, only very few can be named which are superior to the wild type in a strange environment.” Ibid., p. 100.
u “If we say that it is only by chance that they [mutations] are useful, we are still speaking too leniently. In general, they are useless, detrimental, or lethal.” W. R. Thompson, “Introduction to The Origin of Species,” Everyman Library No. 811 (New York: E. P. Dutton & Sons, 1956; reprint, Sussex, England: J. M. Dent and Sons, Ltd., 1967), p. 10.
u Visible mutations are easily detectable genetic changes, such as albinism, dwarfism, and hemophilia. Winchester quantifies the relative frequency of several types of mutations.
Lethal mutations outnumber visibles by about 20 to 1. Mutations that have small harmful effects, the detrimental mutations, are even more frequent than the lethal ones. Winchester, p. 356.
u John W. Klotz, Genes, Genesis, and Evolution, 2nd edition, revised (St. Louis: Concordia Publishing House, 1972), pp. 262–265.
u “... I took a little trouble to find whether a single amino acid change in a hemoglobin mutation is known that doesn’t affect seriously the function of that hemoglobin. One is hard put to find such an instance.” George Wald, as quoted by Murray Eden, “Inadequacies of Neo-Darwinian Evolution as a Scientific Theory,” Mathematical Challenges to the Neo-Darwinian Interpretation of Evolution, editors Paul S. Moorhead and Martin M. Kaplan, pp. 18–19.
However, evolutionists have taught for years that hemoglobin alpha changed through mutations into hemoglobin beta. This would require, at a minimum, 120 point mutations, so the improbability Wald refers to above must be raised to the 120th power to produce just this one protein!
u “Even if we didn’t have a great deal of data on this point, we could still be quite sure on theoretical grounds that mutants would usually be detrimental. For a mutation is a random change of a highly organized, reasonably smoothly functioning living body. A random change in the highly integrated system of chemical processes which constitute life is almost certain to impair it—just as a random interchange of connections in a television set is not likely to improve the picture.” James F. Crow (Professor of Genetics, University of Wisconsin), “Genetic Effects of Radiation,” Bulletin of the Atomic Scientists, Vol. 14, January 1958, pp. 19–20.
u “The one systematic effect of mutation seems to be a tendency towards degeneration ...” [emphasis in original] Sewall Wright, “The Statistical Consequences of Mendelian Heredity in Relation to Speciation,” The New Systematics, editor Julian Huxley (London: Oxford University Press, 1949), p. 174.
Wright then concludes that other factors must also have been involved, because he believes evolution happened.
u In discussing the many mutations needed to produce a new organ, Koestler says:
Each mutation occurring alone would be wiped out before it could be combined with the others. They are all interdependent. The doctrine that their coming together was due to a series of blind coincidences is an affront not only to common sense but to the basic principles of scientific explanation. Arthur Koestler, The Ghost in the Machine (New York: Macmillan Publishing Co., 1968), p. 129.
c . “There is no single instance where it can be maintained that any of the mutants studied has a higher vitality than the mother species.” N. Heribert Nilsson, Synthetische Artbildung (Lund, Sweden: Verlag CWK Gleerup, 1953), p. 1157.
“It is, therefore, absolutely impossible to build a current evolution on mutations or on recombinations.” [emphasis in original] Ibid., p. 1186.
u “No matter how numerous they may be, mutations do not produce any kind of evolution.” Pierre-Paul Grassé, Evolution of Living Organisms (New York: Academic Press, 1977), p. 88.
u “I have seen no evidence whatsoever that these [evolutionary] changes can occur through the accumulation of gradual mutations.” Lynn Margulis, as quoted by Charles Mann, “Lynn Margulis: Science’s Unruly Earth Mother,” Science, Vol. 252, 19 April 1991, p. 379.
u “It is true that nobody thus far has produced a new species or genus, etc., by macromutation. It is equally true that nobody has produced even a species by the selection of micromutations.” Richard B. Goldschmidt, “Evolution, As Viewed by One Geneticist,” American Scientist, Vol. 40, January 1952, p. 94.
u “If life really depends on each gene being as unique as it appears to be, then it is too unique to come into being by chance mutations.” Frank B. Salisbury, “Natural Selection and the Complexity of the Gene,” Nature, Vol. 224, 25 October 1969, p. 342.
u “Do we, therefore, ever see mutations going about the business of producing new structures for selection to work on? No nascent organ has ever been observed emerging, though their origin in pre-functional form is basic to evolutionary theory. Some should be visible today, occurring in organisms at various stages up to integration of a functional new system, but we don’t see them: there is no sign at all of this kind of radical novelty. Neither observation nor controlled experiment has shown natural selection manipulating mutations so as to produce a new gene, hormone, enzyme system or organ.” Michael Pitman, Adam and Evolution (London: Rider & Co., 1984), pp. 67–68.
u For a multifaceted genetic analysis that devastates the idea that mutations and natural selection can produce, or even maintain, viable organisms, see John C. Sanford, Genetic Entropy & the Mystery of the Genome (Waterloo, New York: FMS Publications, 2005).
Last edited by Admin on Mon Oct 19, 2015 6:22 pm; edited 2 times in total
